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KMID : 1139220190150020213
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Journal of Exercise Rehabilitation
2019 Volume.15 No. 2 p.213 ~ p.223
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Low intensity training improves redox status and reduces collagen fibers on dystrophic muscle
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Fernandes Danielle Cristina
Cardoso-Nascimento Jessica Junia A.
Garcia Bruna Caroline C.
Costa Karine Beatriz
Rocha-Vieira Etel
Oliveira Murilo Xavier
Machado Alex Sander D.
Santos Ana Paula
Gaiad Thais Peixoto
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Abstract
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Exercise therapy on skeletal muscle of muscular dystrophies has no defined parameters. The effect of low-intensity treadmill training on the oxidative stress markers and fibrosis on hindlimb muscles was investigated. Sixteen dystrophic male mdx animals were separated in trained (mdxT/n=8) and untrained (mdxNT/n=8) groups. Wild type animals (WT/n=8) were used as healthy control. The mdxT group runned at a horizontal treadmill (9 m/min, 30 min/day, 3 times/wk, 8 weeks). Gastrocnemius and tibial anterior muscles were collected for analysis of enzymatic/non-enzymatic oxidant activity, oxidative damage concentration, collagen fibers area morphometry. The mdxT group presented a lower collagen fiber area compared to mdxNT for gastrocnemius (P=0.025) and tibial anterior (P=0.000). Oxidative damage activity was higher in the mdxT group for both muscles compared to mdxNT. Catalase presented similar activity for tibial anterior (P=0.527) or gastrocnemius (P=0.323). Superoxide dismutase (P=0.003) and total antioxidant capacity (P=0.024) showed increased activity in the mdxT group at tibial anterior with no difference for gastrocnemius. Low-intensity training is considered therapeutic as it reduces collagen deposition while improv-ing tissue redox status.
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KEYWORD
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Duchenne muscular dystrophy, Exercise, Fibrosis, mdx mouse, Redox status
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